Ebola

We have identified 3 molecules (pyronaridine, tilorone and quinacrine) with in vitro activity against three strains of Ebola virus. These three molecules were also active in vivo in a mouse adapted virus model. One molecule Pyronaridine, has to date, shown activity in a guinea pig adapted virus model and is ready to go into a non-human primate model.

We have 3 orphan drug designations for this disease.

Ekins S, Freundlich JS, Clark AM, Anantpadma M, Davey RA, Madrid P.Machine learning models identify molecules active against the Ebola virus in vitro. F1000Res. 2015 Oct 20;4:1091. doi: 10.12688/f1000research.7217.3. eCollection 2015.PMID: 26834994

Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB. Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01711-17. doi: 10.1128/AAC.01711-17. Print 2018 Feb.PMID: 29133569

Lane TR, Comer JE, Freiberg AN, Madrid PB, Ekins S. Repurposing Quinacrine against Ebola Virus Infection In Vivo.Antimicrob Agents Chemother. 2019 Aug 23;63(9):e01142-19. doi: 10.1128/AAC.01142-19. Print 2019 Sep.PMID: 31307979

Lane TR, Massey C, Comer JE, Anantpadma M, Freundlich JS, Davey RA, Madrid PB, Ekins S. Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection.PLoS Negl Trop Dis. 2019 Nov 21;13(11):e0007890. doi: 10.1371/journal.pntd.0007890. eCollection 2019 Nov.PMID: 31751347

Lane TR, Massey C, Comer JE, Freiberg AN, Zhou H, Dyall J, Holbrook MR, Anantpadma M, Davey RA, Madrid PB, Ekins S. Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig. Antiviral Res. 2020 Sep;181:104863. doi: 10.1016/j.antiviral.2020.104863. Epub 2020 Jul 16.PMID: 32682926

Lane TR, Dyall J, Mercer L, Goodin C, Foil DH, Zhou H, Postnikova E, Liang JY, Holbrook MR, Madrid PB, Ekins S. Repurposing Pyramax®, quinacrine and tilorone as treatments for Ebola virus disease. Antiviral Res. 2020 Oct;182:104908. doi: 10.1016/j.antiviral.2020.104908. Epub 2020 Aug 13.PMID: 32798602