Yellow Fever

We have identified several novel inhibitor series for this virus.

Kazakova E, Lane TR, Jones T, Puhl AC, Riabova O, Makarov V, Ekins S. 1-Sulfonyl-3-amino-1H-1,2,4-triazoles as Yellow Fever Virus Inhibitors: Synthesis and Structure-Activity Relationship. ACS Omega. 2023 Nov 1;8(45):42951-42965

Gawriljuk VO, Foil DH, Puhl AC, Zorn KM, Lane TR, Riabova O, Makarov V, Godoy AS, Oliva G, Ekins S. Development of Machine Learning Models and the Discovery of a New Antiviral Compound against Yellow Fever Virus.J Chem Inf Model. 2021 Aug 23;61(8):3804-3813. doi: 10.1021/acs.jcim.1c00460. Epub 2021 Jul 21.PMID: 34286575

Puhl AC, Fernandes RS, Godoy AS, Gil LHVG, Oliva G, Ekins S. The protein disulfide isomerase inhibitor 3-methyltoxoflavin inhibits Chikungunya virus.Bioorg Med Chem. 2023 Apr 1;83:117239. doi: 10.1016/j.bmc.2023.117239. Epub 2023 Mar 15.PMID: 36940609